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Extracellular Vesicle News

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Are You Testing Protein Fractions in Your Extracellular Vesicle Therapeutics Studies? You Should Be.

How can you be sure that the active ingredient in your extracellular vesicle therapeutic is actually in extracellular vesicles?
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Harvesting the Benefits of Plant Extracellular Vesicles

From Arabidopsis thaliana to red cabbage, the field of plant EV (and EV-like nanoparticle) research is a fast-changing world of basic biology and therapeutics. So why is methodology stuck in the past?
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Next-Generation EV Separation: Izon Science and Agarose Bead Technologies Collaborate to Enhance Clinical Applications for Extracellular Vesicles 

The collaborative agreement between Izon Science and ABT offers exceptional opportunities to develop solutions that aid in advancing EV research into clinical settings. 
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Izon Science and Agarose Bead Technologies (ABT) partnership
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Maximising Extracellular Vesicle Output: A Small Bioreactor Goes a Long Way

A summary of work by Hisey et al. (2022) who made a huge leap forward in EV production capacity via the use of flask-based bioreactors.
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Purity Matters: Why Different EV Isolation Methods Give Different Results

Has changing your isolation method changed your EV isolate bioactivity? Or perhaps even their cargo or markers? Here’s why.
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Purity Matters: Why Different EV Isolation Methods Give Different Results
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Buy in Bulk: qEVoriginal Gen 2 Columns

100-packs now available for those looking to buy qEVoriginal Gen 2 columns in bulk.
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Types of Extracellular Vesicles: From Exosomes to Oncosomes and Everything In Between

When is an extracellular vesicle an exosome? Turns out, probably less often than you think. Here we delve into EV subtypes and the (lack of) markers to tell them apart.
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Exploring EVs from a Hospital-Derived Bacterial Pathogen With the Exoid and qEV10

A summary of work by Chiang et al. 2022, feat. qEV and TRPS for studying OMVs from a nosocomial bacterial pathogen.
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Extracellular Vesicles and Preeclampsia: From Pathogenesis to Diagnostics and Therapeutics

Preeclampsia is a major contributor to premature birth. How might extracellular vesicles play a role in pathogenesis, prediction, and treatment?
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Potential Applications of Reproductive Extracellular Vesicles: From Human Fertility to Agriculture and Beyond

The internal reproductive tract is a potential treasure trove of EVs for fields from assistive reproductive technologies to virology. In this article we discuss it all, from isolation to application.
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Synovial Fluid Extracellular Vesicles: Footsoldiers of Inflammation?

Synovial fluid is a highly viscous biofluid containing immune cell-derived extracellular vesicles which could prove key to arthritides, but how should you isolate them? And what is already known about them?
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From Astrocytoma to Preeclampsia: 4 Recent TRPS Articles Spanning the EV Field

Publications featuring Tunable Resistive Pulse Sensing (TRPS) from Q3, 2022.
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Compare 5 Approaches to Milk EV Isolation: Findings From Morozumi et al 2021

A comparison of 5 isolation methods for milk extracellular vesicles: a summary of the findings of Morozumi et al. 2021.
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Extracellular Vesicles From Cerebrospinal Fluid: Current State of the Research

Cerebrospinal Fluid presents unique challenges for EV isolation, which has been reflected in a lack of reproducibility in research.
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Plasma Extracellular Vesicles: Does Anticoagulant Type Matter?

The methods you use for blood collection and processing will impact on the EVs that end up in your isolated sample. Here we discuss the evidence to help you make the right decisions for your research.
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Extracellular Vesicle Isolation: Why Size Exclusion Chromatography Is on the Rise

Size exclusion chromatography is a gentle method for isolating pure, intact and functionally active extracellular vesicles. Here we discuss the pros and cons of SEC and other EV isolation techniques.
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Milk Extracellular Vesicles: Isolation, Function and Future Uses

Isolation, function, and potential future uses of extracellular vesicles derived from milk – a complex and commonly overlooked biofluid.
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Extracellular Vesicles and MicroRNA: Definitions, Discovery, Clinical Potential and Open Questions

Reflecting on the discovery, open questions and potential applications of microRNA, and microRNA derived from extracellular vesicles.
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7 Considerations for Storing Samples Prior to Extracellular Vesicle Isolation

When it comes to EV storage, there are many variables to consider. Here, we share 7 factors to consider between the time of collection until samples are processed for EV isolation.
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World Cancer Day 2022: Addressing Questions in EV-based Biomarker Development

On World Cancer Day 2022, we look to progress and challenges in areas critical to the development of extracellular vesicle-based biomarkers for early cancer detection.
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Tasmanian Devils Endangered: Uncovering EV Biomarkers to Aid Conservation Strategies

The Tasmanian devil species is threatened by transmissible facial tumours. Do extracellular vesicles hold the key to better conservation strategies?
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What Makes Tunable Resistive Pulse Sensing So Precise?

How tunable resistive pulse sensing (TRPS) enables precise EV measurements.
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To Cut Through the Noise in Extracellular Vesicle Analysis, Reproducible Isolation is Essential

Why the signal-to-noise ratio is important for EV-based diagnostics.
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Separation Protocol Opens Doors to Functional EV-Virus Studies

Notes from a conversation with Assistant Professor Stephanie Jung, University Hospital of Bonn (Germany), who separated Hepatitis B and antibodies from EVs to enable functional EV-virology studies.
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4 Reasons Why Storage Conditions Matter for Extracellular Vesicle Research

Four reasons why storage conditions matter to the world of extracellular vesicle research.
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EVs and Glioblastoma Research: Insights from the Field

Sharing the story of France-based researcher Dr Gwennan André-Grégoire, who is working on unravelling the EV-related pathophysiology of glioblastoma multiforme.
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Gwennan André-Grégoire Laetitia Guevel, Julie Gavard and Quentin Sabbagh in their lab
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Proteomic Analysis of Plasma Extracellular Vesicles: A Clinically Relevant SEC-MS Method

An optimised, clinically relevant method for proteomic analysis of plasma EVs, featuring qEV isolation, is now documented in Cell Reports Methods.
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Exploring 4 Fascinating Extracellular Vesicle Studies on World Hepatitis Day 2021

On World Hepatitis Day 2021, we explore how researchers are pursuing extracellular vesicles as a way to improve outcomes for people with hepatitis.
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The Expanding Landscape of Techniques for Nanoplastic and Microplastic Analysis: A Comparative Study

A summary of work by Caputo et al (2021) who conducted a side-by-side comparison of ten analytical techniques for the characterisation of nanoplastics and microplastics.
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Extracellular Vesicles as Propagators of Misfolded Proteins in Neurodegenerative Disease

A summary of the first ISEV 2021 plenary session by Andrew Hill, La Trobe University. This presentation explored EVs and their role in neurogenerative diseases, with a particular focus on prion diseases.
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The Role of Extracellular Vesicles in Cardiovascular Disease

A wrap-up of the second ISEV 2021 plenary talk by Chantal Boulanger, INSERM. Here, the focus was on EVs in relation to arterial contraction and myocardial infarction.
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Bacterial EVs, Cross-Talk and Mucosal Drug Delivery

Highlights from the third ISEV 2021 plenary talk by Simon Carding, University of East Anglia, who discussed bacteria-derived EVs, their dynamics in the gut and their potential as drug delivery vehicles.
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Kits Launched to Enable Standardised EV Concentration and EV-RNA Extraction

Together, the qEV Concentration Kit and qEV RNA Extraction Kit provide streamlined and standardised solutions for isolating and concentrating EVs and extracting EV-RNA for downstream analysis.
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qEV RNA Extraction Kit and qEV Concentration kit for downstream ev analysis
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3 Questions to Ask When Navigating Nanoparticle Analysis and Resolution Limits

To help you select a suitable method for your research, we identified three key questions that get to the core of what’s important for characterising nanoparticles.
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Advances in Zeta Potential Analysis Highlighted at ISEV 2021

How is TRPS used to derive EV characteristics? How has a post-processing protocol created new possibilities for zeta potential analysis? Find out in this wrap-up of the ISEV2021 presentation by Dr. Priscila Dauros-Singorenko.
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Izon's Symposium at ISEV 2021 - Advances in Zeta Potential Analysis
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A Systematic Nanoparticle Analysis Comparison Study Reveals TRPS as a High Performer

In brief: a summary of work by Vogel et al. (2021), who compared six methods for nanoparticle analysis, and assessed their capabilities using synthetic and biological nanovesicles of varying complexity.
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Izon Science Launches the Exoid to Transform Nanoparticle Measurement

To strengthen the analysis of nanoparticle size, concentration, and charge, Izon Science has released the Exoid – a new-generation Tunable Resistive Pulse Sensing (TRPS) technology.
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