Accurate particle sizing using TRPS

Easily determine individual particle size and your real size distribution, with similar accuracy to TEM, in a fraction of the time. You can measure the true sizes of your particles, not the hydro-dynamic diameter that laser based systems measure. The true distribution is automatically provided because a large number of particles are individually measured with high precision and directly compared with traceable calibration particles. There is no subjectivity in TRPS, no software guesstimates and no pre-determined distribution profile. Unlike DLS or NTA, you can have complete confidence that your particles sizes and profile are what the instrument provides. TRPS is simple to understand and to apply.
Exoid right side on
/ 01

Measure particles individually with precision

Physical size, not hydro-dynamic.
/  02

Obtain accurate concentration measurements

On a linear scale, not log scale.
/ 03

Simultaneously measure size & concentration

Allowing you to keep track of your particles.

Measure particles individually, with precision

TRPS provides you with high resolution size and concentration data by measuring a large number of individual particles with extremely high precision using impedance. Each particle’s size is automatically compared with a known calibration standard, which provides both precision and certainty. That means you get the true particle size, not a number generated by an algorithm.
NTA DLS and TRPS comparison graph
Figure 1.
TRPS, NTA and MADLS measurements of quadrimodal sample C (CPN100/CPN150/CPN200/CPN240 at 25/25/25/25). TRPS, NTA and MADLS measurements were averaged over 3 runs. TRPS identifies all four sub populations clearly. NTA was able to identify that multiple sub populations were present. MADLS was not about to identify any sub populations.

Obtain accurate concentration measurements

TRPS is by far the most accurate technique for measuring particle concentration. As with size, the concentration is always derived from direct comparison with calibration particles, providing certainty as well as accuracy. The accuracy, resolution and repeatability of the measurements mean that the usefulness of the particle number is enhanced well beyond providing a single number of particles per mL. Note that, regardless of the technique used, the concentration needs to be defined by the size range covered. The size profile should be presented with the number of particles in each size bin, in histogram format. The detail and repeatability of TRPS concentration measurement allow you to track and control particles through various processes which speeds up your research/development projects. Note that DLS is unable to measure particle concentration at all and NTA is only able to measure it on a semi-quantitative log-scale basis.

Simultaneously measure size & concentration

TRPS is the only technology that can correctly measure individual particle sizes and their concentration at the same time. TRPS uses an elegant pore technology that is quite different and superior to laser based systems. A rich data set is generated which enables a detailed and reliable analysis of the particle set. With the advent of this superior measurement method and the solid data points it provides, researchers can focus on advancing their development and understanding of nano and particularly nano-bio particles.

Standardised real size and concentration data are necessary to show physico-chemical equivalence and to track changes in production methods and output. It is not possible to develop or study nanoparticle systems effectively without this information being routinely available. Only TRPS offers what you need.
exoid trimodal data
Figure 2.
The Exoid is capable of measuring heterogenous samples over a wide size distribution, without the need for multiple measurements or adjustment of settings. Subpopulations can be identified with high resolution and accurately quantified individually.
exoid left side on

Introducing the Exoid

The Exoid is the next generation of TRPS device. The Exoid has the proven quality TRPS technology developed with the previous generation, qNano, but significantly improves the user experience making TRPS measurement easier than ever before.
Learn more about the Exoid

Start a conversation about your research

Latest Articles & News

View All >