
Single-particle technique

Ensemble technique

Wide size range (40 nm–20 µm)

Smaller size range (1 nm –3 µm)

Automated data processing with user-friendly data visualisation interface

Simple protocols

Single-particle resolution

Limited resolution

Number-weighted analysis

Intensity-weighted analysis

Measures actual diameter

Measures hydrodynamic diameter

Can resolve populations in multimodal samples

Cannot resolve multimodal samples

No knowledge of particle properties required

Accurate knowledge of optical properties of particles and dispersant is required.