Measure Complex Nanobiologicals With Tunable Resistive Pulse Sensing

Tunable Resistive Pulse Sensing (TRPS) measures individual particles size, concentration and zeta potential with incredibly high precision and accuracy. TRPS is more accurate than commonly used light scattering techniques that provide bulk estimates. Now used in over 45 countries, and included in over 1000 publications, TRPS is leading the nanoparticle industry by providing a technique that meets the key requirements of scientific precision, accuracy and repeatability.
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Obtain unparalleled accuracy

Measure individual nanoparticles from 40 nm to 2 µm.
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Simultaneously measure size and concentration

Obtain accurate particle concentration in each size band.
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Measure single-particle zeta potential

Measure the zeta potential of each individual particle.
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Measure Individual Particles With Confidence

The precision, resolution and accuracy of size measurement in TRPS is unmatched by any other nanoparticle analysis technique. TRPS measures nanoparticles suspended in electrolytes on a particle-by-particle basis as they pass through a tunable nanopore. When particles pass through they momentarily disrupt the electrical current in the pore, which creates a blockade. The dimensions and frequency of these blockades are used to determine particle size, concentration and zeta potential. Every particle measured is compared to a set of NIST-traceable calibration particles of known size, which ensures accuracy and repeatability.
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Simultaneously measure size and concentration

Using TRPS, you can simultaneously measure particle size and concentration. As particles individually pass through a nanopore, a blockade is created. The magnitude of the blockade is directly proportional to particle size while the frequency of the blockades is used to determine concentration. TRPS can distinguish multiple subpopulations with high resolution, which is an important capability for fields working with polydisperse samples, such as extracellular vesicle (EV) research.
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Figure 1.
The Exoid is capable of measuring heterogenous samples over a wide size distribution, without the need for multiple measurements or adjustment of settings. Subpopulations can be identified with high resolution and accurately quantified individually.
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Measure the Zeta Potential of Individual Particles

With TRPS you can measure particle size and zeta potential (or surface charge) simultaneously. TRPS measures each particle individually ensuring highly precise data collection, a powerful new approach for life sciences.

The single-particle approach used by TRPS makes it much more precise than ensemble approaches, such as PALS.
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Whatever particle you’re measuring, TRPS has you covered

TRPS is used in a wide range of applications including EVs, viruses and virus-like-particles, nanomedicine and other heterogenous nanoparticles. Select your field to read relevant publications and case studies.
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Introducing the Exoid

The Exoid is the next-generation TRPS instrument enabling precise, particle-by-particle analysis that builds on the previous and more manually demanding instrument, the qNano. Released in 2021, the Exoid features in-built advances that retain the precision of TRPS, while providing a more user-friendly experience.
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Skill required for insightful, reliable nanoparticle measurements

Many physical characterisation methods on the market are rapid and require very little effort and skill. However, they do not have the resolving power required for complex samples containing particles of different sizes. Systematic, comparative studies have shown the low resolving capability of these techniques, and the relatively low repeatability compared to TRPS. In contrast, TRPS provides precision via its single-particle nature combined with the use of calibration particles and active monitoring by the user. Even though proper sample preparation, skill, and effort are required for TRPS measurements – particularly for the measurement of particles at the lower end of the size range – it’s the only way forward if you want repeatable data on heterogenous samples containing small particles.

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