The precision, resolution, and accuracy of size measurement in TRPS is unmatched by any other nanoparticle analysis technique. The transient current pulse caused by a particle traversing the pore is directly proportional to particle volume, enabling a highly precise and repeatable measurement of size to be achieved; in ideal conditions TRPS offers sub nm resolution of diameter. Every particle measured is compared to a set of NIST traceable calibration particles of known size, which ensures accuracy and repeatability. This calibration step enables the real size distribution of a particle set to be generated to a very high precision and accuracy. The measurement of particle concentration is also the best available, with data accuracy on a linear scale. By way of comparison, DLS is unable to measure concentration at all, and NTA is only accurate on a log scale and is too coarse for most scientific purposes.

With TRPS users can simultaneously measure particle size and concentration. As particles individually pass through a nanopore it creates a blockade, the magnitude of the blockade is directly proportional to particle size while the frequency of the blockades is used to determine concentration. This is important in fields such as extracellular vesicle investigation as particles are typically heterogeneous. A standardised approach, such as TRPS, to measuring them is required for accurate, replicable, and precise data.