Single-Particle Characterisation of Lipid Nanoparticles and Other Drug Delivery Vectors

Precisely measure the size, concentration and zeta potential of individual lipid nanoparticles (LNPs) and other drug delivery vectors with Tunable Resistive Pulse Sensing (TRPS). With the Exoid and TRPS, you can characterise particles in your formulations with unsurpassed accuracy and single-particle resolution. Ultimately ,the capabilities of the Exoid can give you a clearer path towards product development and quality control.

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Assess Polydispersity

Capture the heterogeneity of particle size as part of your quality control process.

Optimise Process Development

Identify subtle changes to size or concentration that might reflect aggregation during development or storage.

Get Deeper Insights

Obtain high-resolution, single-particle insights rather than bulk estimates.

Acquire and Analyse Numerical Data on Every Particle

Using Tunable Resistive Pulse Sensing (TRPS) via the Exoid, you get in-depth, high-quality data. This contrasts with other methods that simply give you one overall measure of your sample, meaning that it’s relatively easy for differences between samples to go by unrecognised. Instead, the Exoid gathers numerical data on every particle it measures, allowing you to visualise data at a single-particle level. In practice, this means you can use TRPS to assess polydispersity, identify particle subpopulations, aggregation, or even loading-induced changes, thereby determining how different parts of your workflow affect particle characteristics.


A Standardised Approach to Nanoparticle Analysis

There are a few inherent features of the Exoid which allow you, your customers, and governing bodies, to have confidence in the measurements of your nanoparticle formulations. With the use of NIST-traceable calibration particles and real-time reporting of measurement conditions, the Exoid offers an insightful technique for nanomedicine development. While techniques based on light scattering can be subject to errors in Brownian motion calculations with variation in different measurement conditions, the single-particle nature of TRPS means that measurements are not skewed by large or small particles, or the input of optical properties.

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Collect the Data Required for Regulatory Purposes

For your nanomedicine product to reach the market, it must be – and should be – the safest and most effective product that you can make. As nanomedicines enter not just the clinic but the public consciousness, regulations regarding the quality control of lipid nanoparticles and other drug delivery vehicles will come into play. Be ready for this by making the Exoid part of your development and quality control workflows. Only by having the most in-depth and accurate characterisation of your nanoparticles, as is provided by the Exoid, can you be ready for these regulations. Data talks. Make sure that your data tells the full and accurate story when the regulatory bodies come to hear it.


Discover how the Exoid can elevate your nanomedicine R&D