TRPS is well established in the field of nanomedicine as the most precise and accurate method of particle measurement. Single-particle measurements enable the generation of a number-based size distribution, which is not skewed by the presence of subpopulations of large particles and is an essential element of nanomedicine characterisation. As the only technique to provide such data, which will be required for regulatory pathways once specific regulations for nanomedicines come into play, TRPS is a critical aspect of nanomedicine product development. A true representation of the nature of the sample is obtained as subpopulations are revealed and can be individually analysed in terms of particle concentration. Automatic calibration and semi-automated operation mean that user error or inter-operator variation are minimised.
