Extracellular Vesicle News

In Brief: Findings From 5 Publications Harnessing High-Res TRPS Measurements
A brief roundup of findings from 5 studies published in Q2 of 2023 which featured Tunable Resistive Pulse Sensing measurements.

Are You Testing Protein Fractions in Your Extracellular Vesicle Therapeutics Studies? You Should Be.
How can you be sure that the active ingredient in your extracellular vesicle therapeutic is actually in extracellular vesicles?

Harvesting the Benefits of Plant Extracellular Vesicles
From Arabidopsis thaliana to red cabbage, the field of plant EV (and EV-like nanoparticle) research is a fast-changing world of basic biology and therapeutics. So why is methodology stuck in the past?

Next-Generation EV Separation: Izon Science and Agarose Bead Technologies Collaborate to Enhance Clinical Applications for Extracellular Vesicles
The collaborative agreement between Izon Science and ABT offers exceptional opportunities to develop solutions that aid in advancing EV research into clinical settings.

Maximising Extracellular Vesicle Output: A Small Bioreactor Goes a Long Way
A summary of work by Hisey et al. (2022) who made a huge leap forward in EV production capacity via the use of flask-based bioreactors.

A Step-by-Step Guide to (Not) Failing at Extracellular Vesicle Western Blotting
Struggling with Western blots for extracellular vesicles? This guide will help lead you through the process and its pitfalls.

The Exoid in Action: Extracellular Vesicle Studies Revealing New Biological Mechanisms
The Exoid is yet to reach its second birthday, yet it has already appeared in a number of impressive research articles. Here are our top 3 extracellular vesicle studies featuring the Exoid to date.

Purity Matters: Why Different EV Isolation Methods Give Different Results
Has changing your isolation method changed your EV isolate bioactivity? Or perhaps even their cargo or markers? Here’s why.

Buy in Bulk: qEVoriginal Gen 2 Columns
100-packs now available for those looking to buy qEVoriginal Gen 2 columns in bulk.

Types of Extracellular Vesicles: From Exosomes to Oncosomes and Everything In Between
When is an extracellular vesicle an exosome? Turns out, probably less often than you think. Here we delve into EV subtypes and the (lack of) markers to tell them apart.

Urine EVs: A Treasure Trove of Biomarkers in Need of Standardisation
Urine is a rich source of EV biomarkers, yet methodology lags behind modern, standardised technology. New studies show size exclusion chromatography as the way forward.

Exploring EVs from a Hospital-Derived Bacterial Pathogen With the Exoid and qEV10
A summary of work by Chiang et al. 2022, feat. qEV and TRPS for studying OMVs from a nosocomial bacterial pathogen.

Extracellular Vesicles and Preeclampsia: From Pathogenesis to Diagnostics and Therapeutics
Preeclampsia is a major contributor to premature birth. How might extracellular vesicles play a role in pathogenesis, prediction, and treatment?

Potential Applications of Reproductive Extracellular Vesicles: From Human Fertility to Agriculture and Beyond
The internal reproductive tract is a potential treasure trove of EVs for fields from assistive reproductive technologies to virology. In this article we discuss it all, from isolation to application.

Synovial Fluid Extracellular Vesicles: Footsoldiers of Inflammation?
Synovial fluid is a highly viscous biofluid containing immune cell-derived extracellular vesicles which could prove key to arthritides, but how should you isolate them? And what is already known about them?

From Astrocytoma to Preeclampsia: 4 Recent TRPS Articles Spanning the EV Field
Publications featuring Tunable Resistive Pulse Sensing (TRPS) from Q3, 2022.

Compare 5 Approaches to Milk EV Isolation: Findings From Morozumi et al 2021
A comparison of 5 isolation methods for milk extracellular vesicles: a summary of the findings of Morozumi et al. 2021.

Extracellular Vesicles From Cerebrospinal Fluid: Current State of the Research
Cerebrospinal Fluid presents unique challenges for EV isolation, which has been reflected in a lack of reproducibility in research.

Plasma Extracellular Vesicles: Does Anticoagulant Type Matter?
The methods you use for blood collection and processing will impact on the EVs that end up in your isolated sample. Here we discuss the evidence to help you make the right decisions for your research.

Extracellular Vesicle Isolation: Why Size Exclusion Chromatography Is on the Rise
Size exclusion chromatography is a gentle method for isolating pure, intact and functionally active extracellular vesicles. Here we discuss the pros and cons of SEC and other EV isolation techniques.

Milk Extracellular Vesicles: Isolation, Function and Future Uses
Isolation, function, and potential future uses of extracellular vesicles derived from milk – a complex and commonly overlooked biofluid.

Extracellular Vesicles and MicroRNA: Definitions, Discovery, Clinical Potential and Open Questions
Reflecting on the discovery, open questions and potential applications of microRNA, and microRNA derived from extracellular vesicles.

TRPS Provides Fresh Insights Into Effects of Extracellular Vesicle Storage Conditions
In a systematic study by Gelibter et al (2022), TRPS provides a new insight into the effect of extracellular vesicle storage conditions.

7 Considerations for Storing Samples Prior to Extracellular Vesicle Isolation
When it comes to EV storage, there are many variables to consider. Here, we share 7 factors to consider between the time of collection until samples are processed for EV isolation.

Seeking EV Fertility Biomarkers in Dairy Cows Using SWATH-MS
Queensland researchers have embarked on EV/mass spec projects that may improve predictions of dairy cow fertility, and outcomes for pregnant women.

World Cancer Day 2022: Addressing Questions in EV-based Biomarker Development
On World Cancer Day 2022, we look to progress and challenges in areas critical to the development of extracellular vesicle-based biomarkers for early cancer detection.

Tasmanian Devils Endangered: Uncovering EV Biomarkers to Aid Conservation Strategies
The Tasmanian devil species is threatened by transmissible facial tumours. Do extracellular vesicles hold the key to better conservation strategies?

What Makes Tunable Resistive Pulse Sensing So Precise?
How tunable resistive pulse sensing (TRPS) enables precise EV measurements.

To Cut Through the Noise in Extracellular Vesicle Analysis, Reproducible Isolation is Essential
Why the signal-to-noise ratio is important for EV-based diagnostics.

Taking Extracellular Vesicles From Discovery to the Clinic: Requirements, Challenges and General Considerations
What does it take to make an EV biomarker successful?