Purification of Lipid-Based Nanoparticles with the qEV Platform

Glowing Purple Lipid Nanoparticle on a dark background
A dropper releases a single, translucent blue drop from a clear container.

LNP Purification, Without Compromise

Lipid-based nanoparticles are driving innovation in drug delivery, and require gentle, yet efficient, purification for therapeutic development.

The qEV platform harnesses SEC+ to:

  • Isolate LNPs from free lipids, proteins, and impurities

  • Preserve particle integrity with gentle separation

  • Scale easily from research to therapeutic development

Scalable Solutions

Translucent white cylindrical filter with a hexagonal top and bottom, labeled "IZON" in purple

Scale LNP purification with qEV100

  • Isolate sample volumes up to 100 mL
  • Ideal for formulation batches or scaling up LNP production
  • Available in resin series options: 20 nm, 35 nm, and 70 nm
  • Compatible with the qEV Zenco for automation
A white scientific instrument labeled "IZON" features various knobs, connectors, and indicators.

Automate your workflow with the qEV Zenco

  • Streamline LNP purification at 2–400 mL scale
  • Live monitoring of UV trace, pH, conductivity, flow rate, and pressure helps identify purified collection volume and maximise reproducibility
  • Programmable workflows enable running, flushing, cleaning columns between cycles

Prioritise Purity

Isolating lipid-based nanoparticles at high yield doesn’t have to compromise purity.

Our 20 nm and 35 nm resin series delivers maximum recovery of particles, with superior purity compared to TFF - all while preserving particle integrity.

qEV Resin Series

Particle Size Range

Best For

20 nm

20 nm+

Maximising yield

35 nm

35 nm+

Yield and purity balance

70 nm

70 nm+

Maximising purity

Let's support you to therapeutic sooner

As you move from research to therapeutic development, navigating cGMP regulations is critical. Our platform is built to support this transition by offering:

  • cGMP-ready qEV columns

  • qEV Zenco Pro system with cGMP-ready option

  • 21 CFR Part 11–compliant software

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