Meet The Pulsoid
A New Era in Nanoparticle Characterisation
Measure Nanoparticles
Like Never Before
Introducing the Pulsoid, a new particle measurement system built around a silicon chip based nanopore.
It introduces a new technique called Nanopore Pulse Sensing (NPS). By combining proven resistive pulse sensing principles with modern microfabrication, Pulsoid makes single particle analysis fast, repeatable, and accessible.
Size, Concentration & Zeta Potential
Single-particle measurement enables direct insight into size, concentration, and surface charge.
TEM-Level Size Accuracy
Up to 99.7% agreement with TEM, enabled by a solid-state silicon nanopore.
High Throughput, Easy To Learn
2.1x faster than an Exoid. High-resolution data delivered in a streamlined workflow with minimal setup.
See What Ensemble Methods Miss
Ensemble techniques report averages - but important differences between particles can be hidden beneath them.
Pulsoid provides particle-by-particle insights, allowing you to explore distributions, heterogeneity, and subtle population differences that may otherwise go undetected.
TEM-Level Accuracy
High-Resolution Size and Concentration with TEM-Level Size Accuracy.
The precision and consistency of solid-state nanopores enable accurate measurement of small particles from 40 nm and above. Size accuracy is exceptionally high, as demonstrated by the 99.7% agreement with TEM shown below. Single-particle analysis ensures the Pulsoid maintains accuracy even when analysing polydisperse samples.
High-throughput, easy to learn
A solid state silicon nanopore housed in an easy to clean fluid cell reduces handling, maintenance, and calibration between runs. The result is faster workflows and higher throughput.
With a simplified setup and fewer opportunities for user error, Pulsoid requires only a fraction of the setup time of Exoid and delivers around 2× the throughput. It also offers a significantly lower learning curve and more consistent results across users.
True particle-count concentration
Pulsoid measures concentration by directly counting individual particles, delivering a linear response across a wide concentration range of 10⁹ to 10¹² particles per mL.
This ensures measured changes reflect real differences in particle number, not artefacts, making Pulsoid well suited to formulation work, process monitoring, and comparability studies.
Direct, single-particle zeta potential
Pulsoid measures particle size and zeta potential simultaneously on a particle-by-particle basis, revealing charge distributions that ensemble techniques average away. This makes it easier to identify sub-populations, detect
Learn the Principles of NPS Technology
Nanopore Pulse Sensing works by measuring changes in ionic current as individual particles pass through a nanopore.
The size of the decrease in current, also known as a blockade, correlates to the particle size.
The number of blockades is related to the number of particles flowing through the pore, correlating to concentration.
The duration of each blockade is a measure of how long a particle takes to travel through the pore, correlating with zeta potential.
Measure LNPs and Other Nanoparticles
Gain detailed insights into LNPs and other nanoscale materials, measuring size, concentration, and zeta potential.
By combining size and zeta potential measurements in a single workflow, the Pulsoid supports deeper investigation of nanoparticle populations - including the assessment of loaded versus unloaded LNPs.
