qEV Publication Watch: Nov 2021

Extracellular Vesicles
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10 recent qEV-enabled publications across diverse areas of EV research.

1. Choroid plexus-mediated EV release in AD

Importance of extracellular vesicle secretion at the blood–cerebrospinal fluid interface in the pathogenesis of Alzheimer’s disease. Aug 2021, Acta Neuropathologica Communications. doi:10.1186/s40478-021-01245-z

2. EV biosensor development  

An SPRi-based biosensor pilot study: Analysis of multiple circulating extracellular vesicles and hippocampal volume in Alzheimer’s disease. Jan 2021. Journal of Pharmaceutical and Biomedical Analysis. doi:10.1016/j.jpba.2020.113649

3. MicroRNAs, EVs, mesenchymal stem cells and SARS-CoV-2

Potential Therapeutic Effect of MicroRNAs in Extracellular Vesicles from Mesenchymal Stem Cells against SARS-CoV-2. Sep 2021, Cells. doi:10.3390/cells10092393

4. Active cargo loading of EVs

Active cargo loading into extracellular vesicles: Highlights the heterogeneous encapsulation behaviour. Oct 2021, Journal of Extracellular Vesicles. doi:10.1002/jev2.12163

5. EVs as a source of tumour-derived DNA

Extracellular vesicles are the primary source of blood-borne tumour-derived mutant KRAS DNA early in pancreatic cancer. Oct 2021, Journal of Extracellular Vesicles. doi: 10.1002/jev2.12142

6. EVs and spinal cord injury

Extracellular vesicles derived from CD73 modified human umbilical cord mesenchymal stem cells ameliorate inflammation after spinal cord injury. Sep 2021, Journal of Nanobiotechnology. doi:10.1186/s12951-021-01022-z

7. Tau formation in Alzheimer’s disease

Exosomal tau with seeding activity is released from Alzheimer’s disease synapses, and seeding potential is associated with amyloid beta. Aug 2021, Laboratory Investigation. doi:10.1038/s41374-021-00644-z

8. EV proteins and COVID-19 severity

Extracellular vesicle-mediated endothelial apoptosis and EV-associated proteins correlate with COVID-19 disease severity. Jul 2021, Journal of Extracellular Vesicles. doi: 10.1002/jev2.12117

9. Metabolic changes in Parkinson’s disease

Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders. Sep 2021, Acta Neuropathologica. doi:10.1007/s00401-021-02367-3

10. Mechanisms of RNA loading in small EVs

Small Extracellular Vesicle Enrichment of a Retrotransposon-Derived Double-Stranded RNA: A Means to Avoid Autoinflammation? Sep 2021. Biomedicines. doi: 10.3390/biomedicines9091136

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