qEV Publication Watch: Nov 2021

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10 recent qEV-enabled publications across diverse areas of EV research.

1. Choroid plexus-mediated EV release in AD

Importance of extracellular vesicle secretion at the blood–cerebrospinal fluid interface in the pathogenesis of Alzheimer’s disease. Aug 2021, Acta Neuropathologica Communications. doi:10.1186/s40478-021-01245-z

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2. EV biosensor development

An SPRi-based biosensor pilot study: Analysis of multiple circulating extracellular vesicles and hippocampal volume in Alzheimer’s disease. Jan 2021. Journal of Pharmaceutical and Biomedical Analysis. doi:10.1016/j.jpba.2020.113649

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3. MicroRNAs, EVs, mesenchymal stem cells and SARS-CoV-2

Potential Therapeutic Effect of MicroRNAs in Extracellular Vesicles from Mesenchymal Stem Cells against SARS-CoV-2. Sep 2021, Cells. doi:10.3390/cells10092393

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4. Active cargo loading of EVs

Active cargo loading into extracellular vesicles: Highlights the heterogeneous encapsulation behaviour. Oct 2021, Journal of Extracellular Vesicles. doi:10.1002/jev2.12163

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5. EVs as a source of tumour-derived DNA

Extracellular vesicles are the primary source of blood-borne tumour-derived mutant KRAS DNA early in pancreatic cancer. Oct 2021, Journal of Extracellular Vesicles. doi: 10.1002/jev2.12142

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6. EVs and spinal cord injury

Extracellular vesicles derived from CD73 modified human umbilical cord mesenchymal stem cells ameliorate inflammation after spinal cord injury. Sep 2021, Journal of Nanobiotechnology. doi:10.1186/s12951-021-01022-z

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7. Tau formation in Alzheimer’s disease

Exosomal tau with seeding activity is released from Alzheimer’s disease synapses, and seeding potential is associated with amyloid beta. Aug 2021, Laboratory Investigation. doi:10.1038/s41374-021-00644-z

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8. EV proteins and COVID-19 severity

Extracellular vesicle-mediated endothelial apoptosis and EV-associated proteins correlate with COVID-19 disease severity. Jul 2021, Journal of Extracellular Vesicles. doi: 10.1002/jev2.12117

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9. Metabolic changes in Parkinson’s disease

Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders. Sep 2021, Acta Neuropathologica. doi:10.1007/s00401-021-02367-3

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10. Mechanisms of RNA loading in small EVs

Small Extracellular Vesicle Enrichment of a Retrotransposon-Derived Double-Stranded RNA: A Means to Avoid Autoinflammation? Sep 2021. Biomedicines. doi: 10.3390/biomedicines9091136