qEV Publication Watch: Q4 2022

1. Detection of colorectal cancer exosomes using anti-CD63 aptamer and microfluidic chip

Chinnappan, R., Ramadan, Q., Zourob, M. (2022) An integrated lab-on-a-chip platform for pre-concentration and detection of colorectal cancer exosomes using anti-CD63 aptamer as a recognition element. Biosensors and Bioelectronics 220: 114856 https://doi.org/10.1016/j.bios.2022.114856  

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2. Biomarker potential of EV-miRNAome for complications arising from open-heart procedures

Park, H., Kelly, J., Hoffman, J., et al. (2022) Computational analysis of serum-derived extracellular vesicle miRNAs in juvenile sheep model of single stage Fontan procedure. Extracellular Vesicle 1: 100013 https://doi.org/10.1016/j.vesic.2022.100013  

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3. Oviductal cells alter EV production and composition upon contact with spermatozoa

Reshi, Q.U.A., Godakumara, K., Ord, J. et al. (2022). Spermatozoa, acts as an external cue and alters the cargo and production of the extracellular vesicles derived from oviductal epithelial cells in vitro. The Journal of Cell Communication and Signaling. https://doi.org/10.1007/s12079-022-00715-w

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4. Inactivation methods to enable studies of EVs and SARS-CoV-2 particles outside of a BSL-3 certified laboratory

Kongsomros, S., Pongsakul, N., Panachan, J., et al. (2022). Comparison of viral inactivation methods on the characteristics of extracellular vesicles from SARS-CoV-2 infected human lung epithelial cells. Journal of Extracellular Vesicles 11:e12291. https://doi.org/10.1002/jev2.12291  

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5. PGC-1α overexpression in myotubes improves the EV-mediated pro-angiogenic potential

Kargl, C.K., Sullivan, B.P., Middleton, D., et al. (2022). Peroxisome proliferator-activated receptor γ coactivator 1-α overexpression improves angiogenic signalling potential of skeletal muscle-derived extracellular vesicles. Experimental Physiology 1–13. https://doi.org/10.1113/EP090874  

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6. Glycoengineering EVs to improve their cell-targeting traits

Zheng, W., He, R., Liang, X., et al. (2022). Cell-specific targeting of extracellular vesicles though engineering the glycocalyx. Journal of Extracellular Vesicles,11: e12290. https://doi.org/10.1002/jev2.12290  

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7. EVs derived from combined aggregation and co-culture of two types of MSCs are improved in their therapeutic effects

Esmaeili, A., Hosseini, S., Kamali, A. et al. (2022). Co-aggregation of MSC/chondrocyte in a dynamic 3D culture elevates the therapeutic effect of secreted extracellular vesicles on osteoarthritis in a rat model. Scientific Reports 12, 19827 https://doi.org/10.1038/s41598-022-22592-4  

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8. Injectable alginate-collagen hydrogel to improve EVs therapeutic potential in heart: long-term retention and sustained release

Gil-Cabrerizo, P., Saludas, L., Prósper, F., et al. (2022) Development of an injectable alginate-collagen hydrogel for cardiac delivery of extracellular vesicles. International Journal of Pharmaceutics 629: 122356 https://doi.org/10.1016/j.ijpharm.2022.122356  

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9. Using surface enhanced Raman spectroscopy to characterise and distinguish lung cancer-derived EVs

Jonak, S., Liu, Z., Liu, J., et al. (2022) Analyzing bronchoalveolar fluid derived small extracellular vesicles using single-vesicle SERS for non-small cell lung cancer detection. Sensors and Diagnostics, Advance Article https://doi.org/10.1039/d2sd00109h  

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10. Relationship of variants of apolipoproteins and brain-derived EVs with Alzheimer disease

Huang, Y., Driedonks, T., Cheng, L., et al. (2022) Relationships of APOE Genotypes With Small RNA and Protein Cargo of Brain Tissue Extracellular Vesicles From Patients With Late-Stage AD. Neurology: Genetics 8: e200026. https://doi.org/10.1212/NXG.0000000000200026  

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