qEV Publication Watch: Q2 2022

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qEV isolation continues to enable diverse studies on extracellular vesicles.

1. Subset of EVs associated with better prognosis in triple-negative breast cancer  

Tkach M, Thalmensi J, Timperi E, et al. Extracellular vesicles from triple negative breast cancer promote pro-inflammatory macrophages associated with better clinical outcome. Proceedings of the National Academy of Sciences. 2022;119(17). doi:10.1073/pnas.2107394119

2. Methods assessed for isolating EVs from human stool supernatant: qEV the method of choice

Northrop‐Albrecht EJ, Taylor WR, Huang BQ, Kisiel JB, Lucien F. Assessment of extracellular vesicle isolation methods from human stool supernatant. Journal of Extracellular Vesicles. 2022;11(4). doi:10.1002/jev2.12208

3. Surface functionalisation of EVs explored for cancer therapy

Jayasinghe MK, Pirisinu M, Yang Y, et al. Surface-engineered extracellular vesicles for targeted delivery of therapeutic RNAs and peptides for cancer therapy. Theranostics. 2022;12(7). doi:10.7150/thno.68667

4. First report of EV protein biomarkers associated with beryllium exposure, an occupational health hazard

Adduri RSR, Vasireddy R, Mroz MM, et al. Realistic biomarkers from plasma extracellular vesicles for detection of beryllium exposure. International Archives of Occupational and Environmental Health. Published online May 12, 2022. doi:10.1007/s00420-022-01871-7

5. Lipid metabolism helps drive pro-tumorigenic action of lymphoma-derived EVs

Kudo K, Miki Y, Carreras J, et al. Secreted phospholipase A2 modifies extracellular vesicles and accelerates B cell lymphoma. Cell Metabolism. 2022;34(4):615-633.e8. doi:10.1016/j.cmet.2022.02.011

6. Functional delivery of EV cargo demonstrated – along with EV re-release

O’Brien K, Ughetto S, Mahjoum S, Nair AV, Breakefield XO. Uptake, functionality, and re-release of extracellular vesicle-encapsulated cargo. Cell Reports. 2022;39(2):110651. doi:10.1016/j.celrep.2022.110651

7. Exploring post-stroke mechanisms via secretion of glycoprotein LCN2 in astrocytic exosomes

Liu R, Wang J, Chen Y, et al. NOX activation in reactive astrocytes regulates astrocytic LCN2 expression and neurodegeneration. Cell Death & Disease. 2022;13(4):1-15. doi:10.1038/s41419-022-04831-8

8. CRISPR-edited renal cells used to study EV biology in renal cyst disease

Kumar P, Zadjali F, Yao Y, et al. Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicle Production and Trafficking. Biology. 2022;11(5):709. doi:10.3390/biology11050709

9. Ratio of omega-6:omega-3 in sow’s diet impacts EV protein content in milk

Ferreira RF, Blees T, Shakeri F, et al. Effects of different ratios of omega-6:omega-3 fatty acids in the diet of sows on the proteome of milk-derived extracellular vesicles. Journal of Proteomics. 2022;264:104632.

doi:10.1016/j.jprot.2022.104632

10. Novel intervention for colorectal cancer may lie in plant-derived nanovesicles  

Wongkaewkhiaw S, Wongrakpanich A, Krobthong S, Saengsawang W, Chairoungdua A, Boonmuen N. Induction of apoptosis in human colorectal cancer cells by nanovesicles from fingerroot (Boesenbergia rotunda (L.) Mansf.). Chuah LH, ed. PLOS ONE. 2022;17(4):e0266044. doi:10.1371/journal.pone.0266044

In case you missed it: the smallest qEV column has joined the Gen 2 ranks! Read more

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