qEV Publication Watch: Q3 2022

1. Identification of αvβ1 integrin upregulation in EVs from metastatic breast cancer

Zhang, D. X., Dang, X. T. T., Vu, L. T., et al. (2022). αvβ1 integrin is enriched in extracellular vesicles of metastatic breast cancer cells: A mechanism mediated by galectin-3. Journal of Extracellular Vesicles, 11, e12234. https://doi.org/10.1002/jev2.12234

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2. Identification of intermediate SARS-CoV-2 spike protein conformations which could guide design of entry inhibitors

Marcink, T. C., Kicmal, T., Armbruster, E., et al. (2022). Intermediates in SARS-CoV-2 spike-mediated cell entry. Science Advances, 8(33), eabo3153. https://doi.org/10.1126/sciadv.abo3153  

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3. Immunodetection of CD63^+ve EVs down to a magnitude range of 10⁷ EVs/ml

Suthar, J., Alvarez-Fernandez, A., Taylor, A., et al. (2022). Silica Inverse Opal Nanostructured Sensors for Enhanced Immunodetection of Extracellular Vesicles by Quartz Crystal Microbalance with Dissipation Monitoring. ACS Applied Nano Materials. https://doi.org/10.1021/acsanm.2c02775  

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4. Blocking release of HER2^+ve EVs improved the impact of Trastuzumab by reducing HER2 trafficking to the plasma membrane

Hosseini, R., Asef-Kabiri, L., Sarvnaz, H., et al. (2022). Blockade of exosome release alters HER2 trafficking to the plasma membrane and gives a boost to Trastuzumab. Clinical & Translational Oncology, https://doi.org/10.1007/s12094-022-02925-5  

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5. Discovery of a new signature of EV proteins associated with glioblastoma tumor progression

Tzaridis, T., Weller, J., Bachurski, D., et al. (2022). A novel serum extracellular vesicle protein signature to monitor glioblastoma tumor progression. International Journal of Cancer, 10.1002/ijc.34261.  https://doi.org/10.1002/ijc.34261

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6. Identification of two plasma EV proteins able to predict immune adverse reactions to gastric cancer immunotherapy

Jiang F., Zhang Z., Chong X., et al. (2022). Extracellular vesicle-derived protein file from peripheral blood predicts immune-related adverse events in gastric cancer patients receiving immunotherapy. Cancers, 14(17):4167. https://doi.org/10.3390/cancers14174167

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7. Exercise alters EV proteins and size differently in men and women

Conkright, W. R., Beckner, M. E., Sterczala, A. J., et al. (2022). Resistance exercise differentially alters extracellular vesicle size and subpopulation characteristics in healthy men and women: an observational cohort study. Physiological Genomics, 54(9), 350–359. https://doi.org/10.1152/physiolgenomics.00171.2021  

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8. A mass spectrometry method for assessing EV purity using MISEV guidelines puts qEV columns on top

Newman, L. A., Useckaite, Z., & Rowland, A. (2022). Addressing MISEV guidance using targeted LC-MS/MS: A method for the detection and quantification of extracellular vesicle-enriched and contaminant protein markers from blood. Journal of Extracellular Biology, 1, e56. https://doi.org/10.1002/jex2.56  

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9. qEV isolated EVs from canine carcinoma cells had higher functionality than EVs isolated ultracentrifugation

Moccia, V., Sammarco, A., Ferro, S., et al. (2022). Characterization and function of extracellular vesicles in a canine mammary tumour cell line: ultracentrifugation versus size exclusion chromatography. Veterinary and Comparative Oncology. https://doi.org/10.1111/vco.12858  

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‍10. Identification of common Candidia EV proteins contributing to biofilm formation

Zarnowski, R., Sanchez, H., Jaromin, A., et al. (2022). A common vesicle proteome drives fungal biofilm development. Proceedings of the National Academy of Sciences of the United States of America, 119(38), e2211424119. https://doi.org/10.1073/pnas.2211424119  

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