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Exosomes secreted by human urine-derived stem cells accelerate skin wound healing by promoting angiogenesis in rat

Hong Yuan1, Junjie Guan2, Jieyuan Zhang2, Rongming Zhang3,* andMing Li1,*

DOI: 10.1002/cbin.10615

Recent studies have revealed the therapeutic effects of stem cell transplantation that happened through a paracrine mechanism. Exosome is one of the most important paracrine factors that can be directly used in various disease models in the absence of parent cells. Human urine derived stem cells (hUSCs) have shown similar characteristics of mesenchymal stem cells (MSCs) and could also be used to enhance skin wound healing by promoting angiogenesis. We hypothesize that the exosomes derived fromhUSCs (hUSC-Exos) may have pro-angiogenesis ability in wound healing process. The in vitro results showed that the hUSC-Exos could be internalized by human umbilical vein endothelial cells (HUVECs) and thus remarkably enhance HUVECs' proliferation, migration, and tube formation. Transplanting hUSC-Exos to wound sites resulted in accelerated wound closure and re-epithelization. In addition, the angiogenesis of residue tissues was also significantly enhanced. All the findings suggest that hUSC-Exos could facilitate skin wound healing by promoting angiogenesis such that hUSC-Exos can be used as a promising approach for skin wound repair.

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