Search Publications

Third Party Publications

Exosomes in Cancer Diagnostics

Soung, Y. H., Ford, S., Zhang, V., & Chung, J. (2017). Exosomes in Cancer Diagnostics. Cancers, 9(1), 8.

Exosomal miR-146a contributes to the enhanced therapeutic efficacy of IL-1β-primed mesenchymal stem cells against sepsis

Yuxian Song, Huan Dou, Xiujun Li, Xiaoyin Zhao, Yi Li, Dan Liu, Jianjian Ji, Fei Liu, Liang Ding, Yanhong Ni, Yayi Hou

STEM CELLS (2017)

Identification of potential saliva and tear biomarkers in primary Sjögren’s syndrome, utilising the extraction of extracellular vesicles and proteomics analysis

Aqrawi LA, Galtung HK, Vestad B, Øvstebø R, Thiede B, Rusthen S, Young A, Guerreiro EM, Utheim TP, Chen X, Utheim ØA.
Arthritis Research & Therapy. 2017 Jan 25;19(1):14.

Mycobacterium tuberculosis Membrane Vesicles Inhibit T Cell Activation

Jaffre J. Athman, Obondo J. Sande, Sarah G. Groft, Scott M. Reba, Nancy Nagy, Pamela A. Wearsch, Edward T. Richardson, Roxana Rojas, W. Henry Boom, Supriya Shukla and Clifford V. Harding
J Immunol January 25, 2017, 1601199; DOI: https://doi.org/10.4049/jimmunol.1601199

MYC mediates large oncosome-induced fibroblast reprogramming in prostate cancer

Valentina R. Minciacchi, Cristiana Spinelli, Mariana Reis-Sobreiro, Lorenzo Cavallini, Sungyong You, Mandana Zandian, Xiaohong Li, Paola Chiarugi, Rosalyn M Adam, Edwin M Posadas, Giuseppe Viglietto, Michael R Freeman, Emanuele Cocucci, Neil A. Bhowmick and Dolores Di Vizio

DOI: 10.1158/0008-5472.CAN-16-2942

Exosomes Secreted from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Osteonecrosis of the Femoral Head by Promoting Angiogenesis

Liu, Xiaolin, Qing Li, Xin Niu, Bin Hu, Shengbao Chen, Wenqi Song, Jian Ding, Changqing Zhang, and Yang Wang.
International Journal of Biological Sciences 13, no. 2 (2017): 232-244.

Exosomes as Novel Bio-carriers for Gene and Drug Delivery

Jiang, Xin-Chi, and Jian-Qing Gao.
International Journal of Pharmaceutics (2017).

A microRNA signature in circulating exosomes is superior to exosomal glypican-1 levels for diagnosing pancreatic cancer

Lai, Xianyin, Mu Wang, Samantha Deitz McElyea, Stuart Sherman, Michael House, and Murray Korc.
Cancer Letters 393 (2017): 86-93.

Extracellular Vesicle Characteristics in Stored Red Blood Cell Concentrates Are Influenced by the Method of Detection

Almizraq, Ruqayyah J., Jerard Seghatchian, Jelena L. Holovati, and Jason P. Acker. Transfusion and Apheresis Science (2017).

Integration of Stem Cell-Derived Exosomes with In Situ Hydrogel Glue as a Promising Tissue Patch for Articular Cartilage Regeneration

Liu, X., Yang, Y., Li, Y., Niu, X., Zhao, B., Wang, Y., ... & Zhu, L. (2017).
Nanoscale.

Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis

Zhu, Yu, Yuchen Wang, Bizeng Zhao, Xin Niu, Bin Hu, Qing Li, Juntao Zhang, Jian Ding, Yunfeng Chen, and Yang Wang.
Stem Cell Research & Therapy 8, no. 1 (2017): 64.

A Comparative Study of Serum Exosome Isolation Using Differential Ultracentrifugation and Three Commercial Reagents

Helwa, Inas, Jingwen Cai, Michelle D. Drewry, Arthur Zimmerman, Michael B. Dinkins, Mariam Lotfy Khaled, Mutsa Seremwe et al.
PLoS One 12, no. 1 (2017): e0170628.

Exosomes: a new horizon in lung cancer

Vanni, Irene, Angela Alama, Francesco Grossi, Maria Giovanna Dal Bello, and Simona Coco. Drug Discovery Today (2017).

Exosomes derived from mesenchymal non‐small cell lung cancer cells promote chemoresistance

Lobb, Richard J., Rosa van Amerongen, Adrian Wiegmans, Sunyoung Ham, Jill E. Larsen, and Andreas Möller.
International Journal of Cancer (2017).

Isolation of Exosomes from HTLV-Infected Cells

Barclay, R. A., Pleet, M. L., Akpamagbo, Y., Noor, K., Mathiesen, A., & Kashanchi, F. (2017). Isolation of Exosomes from HTLV-Infected Cells. Human T-Lymphotropic Viruses: Methods and Protocols, 57-75.

Augmented liver targeting of exosomes by surface modification with cationized pullulan

Tamura, R., Uemoto, S., & Tabata, Y. (2017). Augmented liver targeting of exosomes by surface modification with cationized pullulan. Acta Biomaterialia.

Cigarette smoke extract induced exosome release is mediated by depletion of exofacial thiols and can be inhibited by thiol-antioxidants

Benedikter, Birke J., et al. "Cigarette smoke extract induced exosome release is mediated by depletion of exofacial thiols and can be inhibited by thiol-antioxidants." Free Radical Biology and Medicine 108 (2017): 334-344.

Quantum dot-based sensitive detection of disease specific exosome in serum

Boriachek, K., Islam, M. N., Gopalan, V., Lam, A. K., Nguyen, N. T., & Shiddiky, M. J. (2017). Quantum dot-based sensitive detection of disease specific exosome in serum. Analyst.
Chicago

The Methods of Choice for Extracellular Vesicles (EVs) Characterization

Szatanek, R., Baj-Krzyworzeka, M., Zimoch, J., Lekka, M., Siedlar, M., & Baran, J. (2017). The Methods of Choice for Extracellular Vesicles (EVs) Characterization. International Journal of Molecular Sciences, 18(6), 1153.

Bead-based flow-cytometry for semi-quantitative analysis of complex membrane vesicle populations released by bacteria and host cells

Volgers, Charlotte, Birke J. Benedikter, Gert E. Grauls, Paul HM Savelkoul, and Frank RM Stassen.
Microbiological Research 200 (2017): 25-32.

Identification of Exosomal Muscle-Specific miRNAs in Serum of Myotonic Dystrophy Patients Relating to Muscle Disease Progress

Koutsoulidou, Andrie, Marinos Photiades, Tassos C. Kyriakides, Kristia Georgiou, Marianna Prokopi, Konstantinos Kapnisis, Anna Łusakowska et al.
Human Molecular Genetics (2017).

Extracellular vesicles are independent metabolic units with asparaginase activity

Iraci, N., Gaude, E., Leonardi, T., Costa, A.S.H., Cossetti, C., Peruzzotti-Jametti, L., Bernstock, J.D., Saini, H.K., Gelati, M., Vescovi, A.L. and Bastos, C., 2017.
Nature chemical biology.

Exosomes as biomarkers and therapeutic tools for type 1 diabetes mellitus

Garcia-Contreras, M., Brooks, R.W., Boccuzzi, L., Robbins, P.D. and Ricordi, C., 2017. Exosomes as biomarkers and therapeutic tools for type 1 diabetes mellitus. Eur Rev Med Pharmacol Sci, 21(12), pp.2940-2956.

Mining Extracellular Vesicles for Clinically Relevant Noninvasive Diagnostic Biomarkers in Cancer

Muhammad Nawaz, Farah Fatima and Jeremy A. Squire (2017). Mining Extracellular Vesicles for Clinically Relevant Noninvasive Diagnostic Biomarkers in Cancer, Novel Implications of Exosomes in Diagnosis and Treatment of Cancer and Infectious Diseases, Prof. Jin Wang (Ed.), InTech, DOI: 10.5772/intechopen.69406

Exosome Isolation: Is There an Optimal Method with Regard to Diagnosis or Treatment?

Mustafa Kotmakçı and Gülşah Erel Akbaba (2017)

Current knowledge on exosome biogenesis and release

Hessvik, Nina Pettersen, and Alicia Llorente.
Cellular and Molecular Life Sciences (2017): 1-16.

Isolation of Biologically Active Exosomes from Plasma of Patients with Cancer

Hong, Chang-Sook, Sonja Funk, and Theresa L. Whiteside. "Isolation of Biologically Active Exosomes from Plasma of Patients with Cancer." In Acute Myeloid Leukemia, pp. 257-265. Humana Press, New York, NY, 2017.

Oncogenic transformation of lung cells results in distinct exosome protein profile similar to the cell of origin

Lobb, Richard J., Marcus L. Hastie, Emma L. Norris, Rosa Amerongen, Jeffrey J. Gorman, and Andreas Möller. "Oncogenic transformation of lung cells results in distinct exosome protein profile similar to the cell of origin." Proteomics (2017).

Biogenesis of Pro-senescent Microparticles by Endothelial Colony Forming Cells from Premature Neonates is driven by SIRT1-Dependent Epigenetic Regulation of MKK6

Simoncini, Stéphanie, Anne-Line Chateau, Stéphane Robert, Dilyana Todorova, Catherine Yzydorzick, Romaric Lacroix, Isabelle Ligi et al.
Scientific Reports 7 (2017).

Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA

Németh, Andrea, Norbert Orgovan, Barbara W. Sódar, Xabier Osteikoetxea, Krisztina Pálóczi, Katalin É. Szabó-Taylor, Krisztina V. Vukman et al. "Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA." Scientific Reports 7 (2017).

Involvement of Interleukin-34 in the Communications between Osteosarcoma and their Microenvironment

Schiavone, K., S. Hunt, H. K. Brown, F. Dechaseaux, A. I. Segaliny, R. Brion, P. Heath, Y. Robin, and D. Heymann. "Involvement of Interleukin-34 in the Communications between Osteosarcoma and their Microenvironment."
Harvard

Exosomes Derived from Mesenchymal Stem Cells Rescue Myocardial Ischaemia/Reperfusion Injury by Inducing Cardiomyocyte Autophagy Via AMPK and Akt Pathways

Liu, Liang, Xian Jin, Cui-Fen Hu, Rong Li, and Cheng-Xing Shen.
Cellular Physiology and Biochemistry 43, no. 1 (2017): 52-68.

Exosomes secreted from mutant-HIF-1α-modified bone-marrow-derived mesenchymal stem cells attenuate early steroid-induced avascular necrosis of femoral head in rabbit

Li, Haile, Danping Liu, Chen Li, Shanjian Zhou, Dachuan Tian, Dawei Xiao, Huan Zhang, Feng Gao, and Jianhua Huang.
Cell Biology International (2017).

Identification of exosomal muscle-specific miRNAs in serum of myotonic dystrophy patients relating to muscle disease progress

Koutsoulidou, Andrie, Marinos Photiades, Tassos C. Kyriakides, Kristia Georgiou, Marianna Prokopi, Konstantinos Kapnisis, Anna Łusakowska et al. Human Molecular Genetics (2017).

Selective release of miRNAs via extracellular vesicles is associated with house dust mite allergen-induced airway inflammation

Gon, Yasuhiro, Shuichiro Maruoka, Toshio Inoue, Kazumichi Kuroda, Kenji Yamagishi, Yutaka Kozu, Sotaro Shikano, Kaori Soda, Jan Lotvall, and Shu Hashimoto.
Clinical & Experimental Allergy (2017).

Effect of exosomes from plasma of dairy cows with or without an infected uterus on prostaglandin production by endometrial cell lines

Almughlliq, Fatema B., Yong Q. Koh, Hassendrini N. Peiris, Kanchan Vaswani, Scott McDougall, Elizabeth M. Graham, Chris R. Burke, and Murray D. Mitchell. Journal of Dairy Science (2017).

Exosomes of human placenta-derived mesenchymal stem cells stimulate angiogenesis

Komaki, Motohiro, Yuri Numata, Chikako Morioka, Izumi Honda, Masayuki Tooi, Naoki Yokoyama, Hirohito Ayame et al.
Stem Cell Research & Therapy 8, no. 1 (2017): 219.

High-purified Isolation and Proteomic Analysis of Urinary Exosomes from Healthy Persons

Yang, Meng, Xiao Zhi, Yanlei Liu, Tianliang Li, Gabriel Alfranca, Fangfang Xia, Chenlu Li, Jie Song, and Daxiang Cui.
Nano Biomed. Eng 9, no. 3 (2017): 221-227.

Extracellular Vesicles: Evolutionarily Conserved Mediators of Intercellular Communication

Lawson, Charlotte, Dory Kovacs, Elizabeth Finding, Emily Ulfelder, and Virginia Luis-Fuentes.
The Yale journal of biology and medicine 90, no. 3 (2017): 481.

Isolation of Exosomes for the Purpose of Protein Cargo Analysis with the Use of Mass Spectrometry

Pietrowska, Monika, Sonja Funk, Marta Gawin, Łukasz Marczak, Agata Abramowicz, Piotr Widłak, and Theresa Whiteside.
In Functional Genomics, pp. 291-307. Humana Press, New York, NY, 2017.

A method for the isolation and enrichment of purified bovine milk exosomes

Vaswani, Kanchan, Yong Qin Koh, Fatema B. Almughlliq, Hassendrini N. Peiris, and Murray D. Mitchell.
Reproductive Biology (2017).

Extracellular vesicles as emerging targets in cancer: Recent development from bench to bedside

Wu, Kerui, Fei Xing, Shih-Ying Wu, and Kounosuke Watabe.
Biochimica et Biophysica Acta (BBA)-Reviews on Cancer (2017).

Exosomal microRNA signatures in multiple sclerosis reflect disease status

Saeideh Ebrahimkhani, Fatemeh Vafaee, Paul E. Young, Suzy S. J. Hur, Simon Hawke, Emma Devenney, Heidi Beadnall, Michael H. Barnett, Catherine M. Suter & Michael E. Buckland
Scientific Reports 7, Article number: 14293 (2017)

Exosomes are defined as submicron (30–150 nm), lipid bilayer-enclosed extracellular vesicles (EVs), specifically generated by the late endosomal compartment through fusion of multivesicular bodies with the plasma membrane. Produced by almost all cells, ex

Willis, Gareth R., Stella Kourembanas, and S. Alex Mitsialis.
Frontiers in Cardiovascular Medicine 4 (2017): 63.

Obstacles and opportunities in the functional analysis of extracellular vesicle RNA – an ISEV position paper

Mateescu, Bogdan, Emma JK Kowal, Bas WM van Balkom, Sabine Bartel, Suvendra N. Bhattacharyya, Edit I. Buzás, Amy H. Buck et al. "Obstacles and opportunities in the functional analysis of extracellular vesicle RNA–an ISEV position paper." Journal of extracellular vesicles 6, no. 1 (2017): 1286095.

Identification and characterization of serovar-independent immunogens in Actinobacillus pleuropneumoniae

Antenucci, Fabio, Cyrielle Fougeroux, Janine T. Bossé, Zofia Magnowska, Camille Roesch, Paul Langford, Peter Johannes Holst, and Anders Miki Bojesen. "Identification and characterization of serovar-independent immunogens in Actinobacillus pleuropneumoniae." Veterinary Research 48, no. 1 (2017): 74.

Adipose-derived circulating miRNAs regulate gene expression in other tissues

Thomou, Thomas, Marcelo A. Mori, Jonathan M. Dreyfuss, Masahiro Konishi, Masaji Sakaguchi, Christian Wolfrum, Tata Nageswara Rao et al. "Adipose-derived circulating miRNAs regulate gene expression in other tissues." Nature 542, no. 7642 (2017): 450-455.

Toward Exosome-Based Therapeutics: Isolation, Heterogeneity, and Fit-for-Purpose Potency

Willis, Gareth R., Stella Kourembanas, and S. Alex Mitsialis. "toward exosome-Based therapeutics: isolation, Heterogeneity, and Fit-for-purpose potency." Frontiers in Cardiovascular Medicine 4 (2017): 63.

Budesonide, fluticasone propionate, and azithromycin do not modulate the membrane vesicle release by THP-1 macrophages and respiratory pathogens during macrophage infection

Volgers, Charlotte, Gert E. Grauls, Pauline HM Hellebrand, Paul HM Savelkoul, and Frank RM Stassen. "Budesonide, fluticasone propionate, and azithromycin do not modulate the membrane vesicle release by THP-1 macrophages and respiratory pathogens during macrophage infection." Inflammopharmacology (2017): 1-9.

Exosome Isolation: Is There an Optimal Method with Regard to Diagnosis or Treatment?

Kotmakçı, Mustafa, and Gülşah Erel Akbaba. "Exosome Isolation: Is There an Optimal Method with Regard to Diagnosis or Treatment?." In Novel Implications of Exosomes in Diagnosis and Treatment of Cancer and Infectious Diseases. InTech, 2017.

Mimicking respiratory phosphorylation using purified enzymes

Christoph von Ballmoos, Olivier Biner, Tobias Nilsson, Peter Brzezinski

Elsevier B.V. Volume 1857, Issue 4, April 2016, Pages 321–331

Cardiovascular Progenitor-Derived Extracellular Vesicles Recapitulate the Beneficial Effects of their Parent Cells in the Treatment of Chronic Heart Failure

Anaïs Kervadec, Valérie Bellamy, Nadia El Harane, Lousineh Arakélian, Valérie Vanneaux, Isabelle Cacciapuoti, Hany Nemetalla, Marie-Cécile Périer, Hadi D Toeg, Adèle Richart, Mathilde Lemitre, Min Yin, Xavier Loyer, Jérôme Larghero, Albert Hagège, Marc Ruel, Chantal M. Boulanger, Jean-Sébastien Silvestre, Philippe Menasché, Nisa KE Renault

The journal of Heart and Lung Transplantation. January 19, 2016

Extracellular vesicles in cardiovascular disease: are they Jedi or Sith?

Xabier Osteikoetxea, Andrea Németh, Barbara W Sódar, Krisztina V Vukman,

The Journal of Physiology, 20 MAR 2016. 10.1113/JP271336

Comparative Analysis of Technologies for Quantifying Extracellular Vesicles (EVs) in Clinical Cerebrospinal Fluids (CSF)

Johnny C. Akers, Valya Ramakrishnan, John P. Nolan, Erika Duggan, Chia-Chun Fu, Fred H. Hochberg, Clark C. Chen, Bob S. Carter

Plos. February 22, 2016

Extracellular vesicles isolated from brains of rTg4510 mice seed tau aggregation in a threshold-dependent manner

Juan Carlos Polanco1, Benjamin James Scicluna2, Andrew Francis Hill3 and Jürgen Götz1*

doi: 10.1074/jbc.M115.709485
March 30, 2016

ISOLATION OF BIOLOGICALLY ACTIVE AND MORPHOLOGICALLY INTACT EXOSOMES FROM PLASMA OF PATIENTS WITH CANCER

Chang-Sook Hong1, Sonja Funk1,2, Laurent Muller1,3, Michael Boyiadzis4 and Theresa L. Whiteside1*

Published: 24 March 2016. Journal of Extracellular Vesicles 2016

Exosomes secreted by human urine-derived stem cells accelerate skin wound healing by promoting angiogenesis in rat

Hong Yuan1, Junjie Guan2, Jieyuan Zhang2, Rongming Zhang3,* andMing Li1,*

DOI: 10.1002/cbin.10615

Preanalytical, analytical, and biological variation of blood plasma submicron particle levels measured with nanoparticle tracking analysis and tunable resistive pulse sensing

Morten Mørkab, Shona Pedersenabc, Jaco Bothaa, Sigrid Marie Lunda & Søren Risom Kristensenabc

Exosomes Secreted by Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Repair Critical-Sized Bone Defects through Enhanced Angiogenesis and Osteogenesis in Osteoporotic Rats

Xin Qi1*, Jieyuan Zhang1,2*, Hong Yuan3, Zhengliang Xu1, Qing Li2, Xin Niu2, Bin Hu2, Yang Wang2,Xiaolin Li1
International Journal of Biological Sciences
2016; 12(7): 836-849. doi: 10.7150/ijbs.14809

Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection

Barbara W Sódar1, Ágnes Kittel2, Krisztina Pálóczi1, Krisztina V Vukman1,
Xabier Osteikoetxea1, Katalin Szabó-Taylor1, Andrea Németh1, Beáta Sperlágh2,
Tamás Baranyai3, Zoltán Giricz3, Zoltán Wiener1, Lilla Turiák4, László Drahos4, Éva Pállinger1,
Károly Vékey4, Péter Ferdinandy3, András Falus1 & Edit Irén Buzás

Published: 18 April 2016 by Scientific Reports

Delivery of membrane proteins into small and giant unilamellar vesicles by charge-mediated fusion

Oliver Biner1,2*, Thomas Schick1,2*, Yannic Müller1, and Christoph von Ballmoos1

1 Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012
Bern, Switzerland
2 Graduate School for Cellular and Biomedical Sciences, University of Bern, Switzerland

Accepted Date : 27-May-2016

Extracellular vesicles are transferred from melanocytes to keratinocytes after UVA irradiation

Petra Wäster, Ida Eriksson, Linda Vainikka, Inger Rosdahl & Karin Öllinger

doi:10.1038/srep27890.
Published online:13 June 2016

The role of extracellular vesicle and tunneling nanotube-mediated intercellular cross-talk between mesenchymal stem cells and human peripheral T cells

Zsolt Matula, Andrea Németh, Péter Lőrincz, Aron Szepesi, Anna Brózik , Edit Irén Buzás, Péter Lőw, Katalin Német, Ferenc Uher, Veronika Urbán

Stem Cells and Development, 2016

Role of OmpA2 surface regions of Porphyromonas gingivalis in host–pathogen interactions with oral epithelial cells

Kathryn L. Naylor, Magdalena Widziolek, Stuart Hunt, Mary Conolly, Matthew Hicks, Prachi Stafford, Jan Potempa, Craig Murdoch, C.W. Ian Douglas, Graham P. Stafford

MicrobiologyOpen, 2016.

Diverse impact of xeno-free conditions on biological and regenerative properties of hUC-MSCs and their extracellular vesicles

Sylwia Bobis-Wozowicz, Katarzyna Kmiotek, Karolina Kania, Elzbieta Karnas, Anna Labedz-Maslowska, Malgorzata Sekula, Sylwia Kedracka-Krok, Jacek Kolcz, Dariusz Boruczkowski, Zbigniew Madeja, Ewa K. Zuba-Surma

J Mol Med, 2016

Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer

Carolina Soekmadji, James D. Riches, Pamela J. Russell, Jayde E. Ruelcke, Stephen McPherson, Chenwei Wang, Chris M. Hovens, Niall M. Corcoran, The Australian Prostate Cancer Collaboration BioResource, Michelle M. Hill, Colleen C. Nelson

A Standardized Method To Determine the Concentration of Extracellular Vesicles using Tunable Resistive Pulse Sensing

Robert Vogel1,2, Frank A. W. Coumans3, Raluca G. Maltesen4, Anita N. Böing3, Katherine E. Bonnington5, Marike L. Broekman6, Murray F. Broom2, Edit I. Buzás7, Gunna Christiansen8, Najat Hajji3, Søren R. Kristensen4, Meta J. Kuehn5, Sigrid M. Lund4, Sybren L. N. Maas6, Rienk Nieuwland3, Xabier Osteikoetxea7, Rosalie Schnoor6, Benjamin J. Scicluna9,10, Mitch Shambrook10, Jeroen de Vrij6, Stephen I. Mann2, Andrew F. Hill9,10 and Shona Pedersen4*

Journal of Extracellular Vesicles 2016, 5: 31242

Exosome-based tumor antigenseadjuvant co-delivery utilizing genetically engineered tumor cell-derived exosomes with immunostimulatory CpG DNA

Morishita, M., Takahashi, Y., Matsumoto, A., Nishikawa, M., & Takakura, Y. (2016). Exosome-based tumor antigens–adjuvant co-delivery utilizing genetically engineered tumor cell-derived exosomes with immunostimulatory CpG DNA. Biomaterials, 111, 55-65.

Trehalose prevents aggregation of exosomes and cryodamage

Ste Bosch, Laurence de Beaurepaire, Marie Allard, Mathilde Mosser, Claire Heichette, Denis Chrétien, Dominique Jegou & Jean-Marie Bach.

Bosch, S., de Beaurepaire, L., Allard, M., Mosser, M., Heichette, C., Chrétien, D., ... & Bach, J. M. (2016). Trehalose prevents aggregation of exosomes and cryodamage. Scientific Reports, 6, 36162.

Macrophages redirect phagocytosis by non- professional phagocytes and influence inflammation

Claudia Z. han, Ignacio J. Juncadella, Jason M. Kinchen, Monica W. Buckley, Alexander L. Klibanov, Kelly Dryden, Suna onengut-Gumuscu, Uta Erdbrügger, Stephen D. turner, Yun M. Shim, Kenneth S. tung, & Kodi S. Ravichandran.

Han, C. Z., Juncadella, I. J., Kinchen, J. M., Buckley, M. W., Klibanov, A. L., Dryden, K., ... & Tung, K. S. (2016). Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation. Nature.
Chicago

Interspecies Communication between Pathogens and Immune Cells via Bacterial Membrane Vesicles

Jurkoshek, K. S., Wang, Y., Athman, J. J., Barton, M. R., & Wearsch, P. A. (2016). Interspecies Communication between Pathogens and Immune Cells via Bacterial Membrane Vesicles. Frontiers in Cell and Developmental Biology, 4, 125.

Urinary extracellular vesicles – potential biomarkers of renal function in diabetic patients

Kamińska, A., Platt, M., Kasprzyk, J., Kuśnierz-Cabala, B., Gala-Błądzińska, A., Woźnicka, O., ... & Stępień, E. Ł. Urinary extracellular vesicles–potential biomarkers of renal function in diabetic patients.

Plasma vesicle miRNAs for therapy response monitoring in Hodgkin lymphoma patients

Monique A.J. van Eijndhoven, Josée M. Zijlstra, Nils J. Groenewegen, Esther E.E. Drees, Stuart van Niele, S. Rubina Baglio, Danijela Koppers-Lalic, Hans van der Voorn, Sten F.W.M. Libregts, Marca H.M. Wauben, Renee X. de Menezes, Jan R.T. van Weering, Rienk Nieuwland, Lydia Visser, Anke van den Berg, Daphne de Jong, and D. Michiel Pegtel

JCI Insight, 1(19).

Digital Detection of Exosomes by Interferometric Imaging

Daaboul, G. G., Gagni, P., Benussi, L., Bettotti, P., Ciani, M., Cretich, M., ... & Prosperi, D. (2016). Digital Detection of Exosomes by Interferometric Imaging. Scientific Reports, 6, 37246.

Exosomes Derived from Human Endothelial Progenitor Cells Accelerate Cutaneous Wound Healing by Promoting Angiogenesis Through Erk1/2 Signaling

Zhang, J., Chen, C., Hu, B., Niu, X., Liu, X., Zhang, G., ... & Wang, Y. (2016). Exosomes Derived from Human Endothelial Progenitor Cells Accelerate Cutaneous Wound Healing by Promoting Angiogenesis Through Erk1/2 Signaling. International Journal of Biological Sciences, 12(12), 1472-1487.
Chicago

Immunosuppressive effect of mesenchymal stem cell-derived exosomes on a concanavalin A-induced liver injury model

Tamura, R., Uemoto, S., & Tabata, Y. (2016). Immunosuppressive effect of mesenchymal stem cell-derived exosomes on a concanavalin A-induced liver injury model. Inflammation and Regeneration, 36(1), 26.

Tunable Resistive Pulse Sensing for the Characterization of Extracellular Vesicles

Sybren L.N. Maas, Marike L.D. Broekman, and Jeroen de Vrij

Exosomes from iPSCs Delivering siRNA Attenuate Intracellular Adhesion Molecule-1 Expression and Neutrophils Adhesion in Pulmonary Microvascular Endothelial Cellsression and Neutrophils Adhesion in Pulmonary Microvascular Endothelial Cells

Zhihai Ju, Jinhui Ma, Chen Wang, Jie Yu, Yeru Qiao and Feilong Hei
(2016) Inflammation, 1-11.

Lysozyme association with circulating RNA, extracellular vesicles, and chronic stress

Abey, S. K., Yuana, Y., Joseph, P. V., Kenea, N. D., Fourie, N. H., Sherwin, L. B., ... & Weaver, K. R. (2016). Lysozyme association with circulating RNA, extracellular vesicles, and chronic stress. BBA Clinical.

Detection of tissue factor-positive extracellular vesicles by laser scanning confocal microscopy

Hisada, Y., Auriemma, A. C., Alexander, W., Ay, C., & Mackman, N. (2016). Detection of tissue factor-positive extracellular vesicles by laser scanning confocal microscopy. Thrombosis Research.

Microfluidic approaches for isolation, detection, and characterization of extracellular vesicles: Current status and future directions

Gholizadeh, Shima, Mohamed Draz, Maryam Zarghooni, Amir Sanati Nezhad, Saeid Ghavami, Hadi Shafiee, and Mohsen Akbari.
Biosensors and Bioelectronics (2016).

Multivesicular body formation enhancement and exosome release during endoplasmic reticulum stress

Kanemoto, Soshi, Ryota Nitani, Tatsuhiko Murakami, Masayuki Kaneko, Rie Asada, Koji Matsuhisa, Atsushi Saito, and Kazunori Imaizumi. "Multivesicular body formation enhancement and exosome release during endoplasmic reticulum stress." Biochemical and biophysical research communications 480, no. 2 (2016): 166-172.

Size-Exclusion Chromatography- based isolation minimally alters Extracellular Vesicles’ characteristics compared to precipitating agents

Gámez-Valero, Ana, Marta Monguió-Tortajada, Laura Carreras-Planella, Katrin Beyer, and Francesc E. Borràs. "Size-Exclusion Chromatography-based isolation minimally alters Extracellular Vesicles’ characteristics compared to precipitating agents." Scientific reports 6 (2016): srep33641.

Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration

Yoshihiro Nakamura; Shigeru Miyaki; Hiroyuki Ishitobi; Sho Matsuyama; Tomoyuki Nakasa; Naosuke Kamei; Takayuki Akimoto; Yukihito Higashi; Mitsuo Ochi
FEBS Letters, 2015

Analysis of exosome purification methods using a model liposome system and tunable-resistive pulse sensing

Rebecca E Lane; Darren Korbie; Will Anderson; Ramanathan Vaidyanathan; Matt Trau
Scientific Reports, 2015 - 5: : 7639

The non-targeted effects of radiation are perpetuated by exosomes

Ammar Al-Mayah, Scott Bright, Kim Chapman, Sarah Irons, Ping Luo, David Carter, Edwin Goodwin, Munira Kadhim
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2015 - 772: : 38-45

Analysis of bacteria-derived outer membrane vesicles using tunable resistive pulse sensing

Evgeny Bogomolny, Jiwon Hong, Cherie Blenkiron, Denis Simonov, Priscila Dauros, Simon Swift, Anthony Phillips, Geoff R. Willmott
Proc. SPIE, 2015 - 9338: : 93381K-93381K-6

Glioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells

J de Vrij, SLN Maas, KMC Kwappenberg, R Schnoor, A Kleijn, L Dekker, TM Luider, LD de Witte, M Litjens, ME van Strien, EM Hol, J Kroonen, PA Robe , ML Lamfers, MW Schilham , MLD Broekman
International Journal of Cancer, 2015

Applications of Tunable Resistive Pulse Sensing

Eva Weatherall and Geoff R. Willmott
Analyst, 2015

Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury

Zhang, Y; Chopp, M; Meng, Y; Katakowski, M; Xin, H; Mahmood, A; Xiong, Y.
Journal of Neurosurgery, 2015 : 1-12

Emergence of tunable resistive pulse sensing as a biosensor

E. Blundell, L. Mayne, E. R. Billinge, M. Platt
Anal. Methods, (2015) advanced article

Purification and Characterization of extracellular vesicles from a 2 hyperthermophilic archaeon Thermococcus onnurineus NA1T

Dong Hee Choia, Yong Min Kwona, Hiroshi Xavier Chiurab, Eun Chan Yang, Seung Seob Bae, Sung Gyun Kanga, Jung-Hyun Leea, Hwan Su Yoone and Sang-Jin Kima,

Applied and Environmental Microbiology, 2015-

NON-TARGETED EFFECTS OF RADIATION EXPOSURE:RECENT ADVANCES AND IMPLICATIONS

M. A. Kadhim and M. A. Hill

Radiation Protection Dosimetry- 2015

Observations of tunable resistive pulse sensing for exosome analysis: Improving system sensitivity and stability

Will Anderson , Rebecca Emily Lane , Darren Korbie , and Matt Trau

Langmuir

Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals

Journal of Extracellular Vesicles 2015, 4: 27378
Armando de Menezes-Neto1, María José Fidalgo Sáez2, Inés Lozano-Ramos3, Joan Segui-Barber1, Lorena Martin-Jaular1, Josep M. Estanyol Ullate2, Carmen Fernandez-Becerra1, Francesc E. Borrás3,4 and Hernando A. del Portillo1,5

Differential detergent sensitivity of extracellular vesicle subpopulations

Xabier Osteikoetxea,a Barbara Sódar,a Andrea Németh,a Katalin Szabó-Taylor,a Krisztina Pálóczi,a Krisztina V. Vukman,a Viola Tamási,a Andrea Balogh,b Ágnes Kittel,c Éva Pállingera and Edit Irén Buzás

The Royal Society of Chemistry: Organic & Biomolecular Chemistry
DOI: 10.1039/c5ob01451d

Improved Characterization of EV Preparations Based on Protein to Lipid Ratio and Lipid Properties

XabierOsteikoetxea1, AndreaBalogh2, KatalinSzabó-Taylor1, AndreaNémeth1, Tamás GézaSzabó1, KrisztinaPálóczi1, BarbaraSódar1, ÁgnesKittel3, BenceGyörgy4,1, ÉvaPállinger1, JánosMatkó2, EditIrénBuzás1

PLOSONE|DOI:10.1371/journal.pone.0121184 March23,2015

Optimized exosome isolation protocol for cell culture supernatant and human plasma

Lobb, Richard J., Melanie Becker, Shu Wen Wen, Christina SF Wong, Adrian P. Wiegmans, Antoine Leimgruber, and Andreas Möller. "Optimized exosome isolation protocol for cell culture supernatant and human plasma." Journal of extracellular vesicles 4, no. 1 (2015): 27031.

Detecting Exosomes Specifically: A Multiplexed Device Based on Alternating Current Electrohydrodynamic Induced Nanoshearing

Ramanathan Vaidyanathan; Maedeh Naghibosadat; Sakandar Rauf; Darren Korbie; Laura Carrascosa; Muhammad Shiddiky; Matt Trau
Analytical Chemistry, 2014 - 86 (22): 11125–11132

Single-step isolation of extracellular vesicles by size-exclusion chromatography

Anita N. Böing, Edwin van der Pol, Anita E. Grootemaat, Frank A. W. Coumans, Auguste Sturk and Rienk Nieuwland
Journal of Extracellular Vesicles, 2014 - 3:

The neutral sphingomyelinase pathway regulates packaging of the prion protein into exosomes

Belinda B. Guo, Shayne A. Bellingham and Andrew F. Hill
Journal of Biological Chemistry, 2014

Protocol Standardization Reveals MV Correlation to Healthy Donor BMI

P Hexley, KP Rismiller, CT Robinson, GF Babcock.
Exosomes Microvesicles, 2014 - 2 (2)

Bioinspired protein microparticles fabrication by peptide mediated disulfide interchange

Lai, Kwok Kei; Renneberg, Reinhard; Mak, Wing Cheung.
RSC Advances, 2014 - 4 (23): 11802-11810

Exosome-formed synthetic microRNA-143 is transferred to osteosarcoma cells and inhibits their migration

Shimbo, Keisuke; Miyaki, Shigeru; Ishitobi, Hiroyuki; Kato, Yoshio; Kubo, Tadahiko; Shimose, Shoji; Ochi, Mitsuo.
Biochemical and biophysical research communications, 2014

Critical role of extracellular vesicles in modulating the cellular effects of cytokines

Szabo GT, Tarr B, Paloczi K, Eder K, Lajko E, Kittel A, Toth S, Gyorgy B, Pasztoi M, Nemeth A, Osteikoetxea X, Pallinger E, Falus A, Szabo-Taylor K, Buzas EI.
Cellular and Molecular Life Sciences, 2014

Particle size distribution of exosomes and microvesicles by transmission electron microscopy, flow cytometry, nanoparticle tracking analysis, and resistive pulse sensing

Pol, E; Coumans, FAW; Grootemaat, AE; Gardiner, C; Sargent, IL; Harrison, P; Sturk, A; Leeuwen, TG; Nieuwland, R.
Journal of Thrombosis and Haemostasis, 2014

Platelet microparticles: detection and assessment of their paradoxical functional roles in disease and regenerative medicine

Burnouf, Thierry; Goubran, Hadi Alphonse; Chou, Ming-Li; Devos, David; Radosevic, Mirjana.
Blood Reviews, 2014

Toward routine detection of extracellular vesicles in clinical samples

R. van der Meel, M. Krawczyk-Durka, W. W. van Solinge and R. M. Schiffelers.
International journal of laboratory hematology, 2014 - 36 (3): 244-253

Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell-free blood

Cheng, Lesley; Sharples, Robyn A; Scicluna, Benjamin J; Hill, Andrew F.
Journal of extracellular vesicles, 2014 - 3:

Lipoprotein-apheresis reduces circulating microparticles in individuals with familial hypercholesterolemia

Connolly, K.D., Willis, G.R., Datta, D.B.N., Ellins, E.A., Ladell, K., Price, D.A., Guschina, I.A., Rees, D.A., James, P.E.Journal of Lipid Research
Volume 55, Issue 10, 1 October 2014, Pages 2064-2072

Quantification and size-profiling of extracellular vesicles using tunable resistive pulse sensing.

Maas SL, De Vrij J, Broekman ML
Journal of Visualized Experiments (92), e51623, doi:10.3791/51623

Standardization of sample collection,isolation and analysis methods inextracellular vesicle research

Kenneth W. Witwer, Edit I. Buzas, Lynne T. Bemis,Adriana Bora, Cecilia Lasser, Jan Lotvall, Esther N. Nolte-‘t Hoen, Melissa G. Piper, Sarada Sivaraman, Johan Skog, Clotilde Thery, Marca H. Wauben and Fred Hochberg
Journal of Extracellular Vesicles, 2013 - 2:

Quantification of nanosized extracellular membrane vesicles with scanning ion occlusion sensing

de Vrij, Maas SL, van Nispen M, Sena-Esteves M, Limpens RW, Koster AJ, Leenstra S, Lamfers ML, Broekman ML
Nanomedicine, 2013 - 8 (9): 1443-58

Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes

Katsuda, Takeshi; Tsuchiya, Reiko; Kosaka, Nobuyoshi; Yoshioka, Yusuke; Takagaki, Kentaro; Oki, Katsuyuki; Takeshita, Fumitaka; Sakai, Yasuyuki; Kuroda, Masahiko; Ochiya, Takahiro.
Scientific reports, 2013 - 3:

Endometrial exosomes/microvesicles in the uterine microenvironment: A new paradigm for embryo-endometrial cross talk at implantation

Ng, York Hunt; Rome, Sophie; Jalabert, Audrey; Forterre, Alexis; Singh, Harmeet; Hincks, Cassandra L; Salamonsen, Lois A.
PloS one, 2013 - 8 (3): e58502

Active caspase-3 is removed from cells by release of caspase-3-enriched vesicles

Boing AN, Stap J, Hau CM, Afink GB, Ris-Stalpers C, Reits EA, Sturk A, van Noorden CJ, Nieuwland R.
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 2013 - 1833 (8): 1844-1852

Innovation in detection of microparticles and exosomes

Pol, E; Coumans, F; Varga, Z; Krumrey, M; Nieuwland, R.
Journal of Thrombosis and Haemostasis, 2013 - 11: : 36-45

Label-free optical monitoring of surface adhesion of extracellular vesicles by grating coupled interferometry

D. Patko, B. Gyorgy, A. Nemeth, K. E. Szabo-Taylor, A Kittel, E. I Buzas, R. Horvath.
Sensors and Actuators B: Chemical, 2013 - 188: : 697-701

Antigen-loaded pH-sensitive hydrogel microparticles are taken up by dendritic cells with no requirement for targeting antibodies

Ruff LE, Mahmoud EA, Sankaranarayanan J, Morachis JM, Katayama CD, Corr M, Hedrick SM, Almutairi A.
Integrative Biology, 2013 - 5 (1): 195-203

Surface Glycosylation Profiles of Urine Extracellular Vesicles

Gerlach JQ, Kruger A, Gallogly S, Hanley SA, Hogan MC, Ward CJ, Joshi L, Griffin MD.
PloS one, 2013 - 8 (9): e74801

Characterization and deep sequencing analysis of exosomal and non-exosomal miRNA in human urine

Cheng, Lesley; Sun, Xin; Scicluna, Benjamin J; Coleman, Bradley M; Hill, Andrew F.
Kidney international, 2013

ISEV position paper: extracellular vesicle RNA analysis and bioinformatics

Hill, Andrew F; Pegtel, D Michiel; Lambertz, Ulrike; Leonardi, Tommaso; O'Driscoll, Lorraine; Pluchino, Stefano; Ter-Ovanesyan, Dmitry; Nolte, Esther NM.
Journal of extracellular vesicles, 2013 - 2:

Polymer−Liposome Complexes with a Functional Hydrogen-Bond Cross-Linker for Preventing Protein Adsorption and Improving Tumor Accumulation

Chiang, Y.-T., Cheng, Y.-T., Lu, C.-Y., Yen, Y.-W., Yu, L.-Y., Yu, K.-S., Lyu, S.-Y., Yang, C.-Y., Lo, C.-L.
Chemistry of Materials. Volume 25, Issue 21, 12 November 2013, Pages 4364-4372

Alternative methods for characterization of extracellular vesicles

Momen-Heravi, Fatemeh; Balaj, Leonora; Alian, Sara; Tigges, John; Toxavidis, Vasilis; Ericsson, Maria; Distel, Robert J; Ivanov, Alexander R; Skog, Johan; Kuo, Winston Patrick.
Frontiers in physiology, 2012 - 3:

Detection and isolation of cell-derived microparticles are compromised by protein complexes resulting from shared biophysical parameters

Bence György1, Károly Módos2, Éva Pállinger1, Krisztina Pálóczi1, Mária Pásztói1,3, Petra Misják1, Mária A. Deli4, Áron Sipos5, Anikó Szalai5, István Voszka2, Anna Polgár6, Kálmán Tóth7, Mária Csete5, György Nagy1,8, Steffen Gay9, András Falus1,3, Ágnes Kittel*,10, and Edit I. Buzás*

DOI: http://dx.doi.org/10.1182/blood-2010-09-307595 by American Society of Hematology

Portable nanoparticle quantization using a resizable nanopore instrument-The IZON qNano

Conference proceedings : Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
2010, Pages 5736-5739

Possibilities and limitations of current technologies for quantification of biological extracellular vesicles and synthetic mimics.

Maas SL, de Vrij J, van der Vlist EJ, Geragousian B, van Bloois L, Mastrobattista E, Schiffelers RM, Wauben MH, Broekman ML, Nolte-'t Hoen EN

Journal of Controlled Release, 200:87-96

Mesenteric lymph node stromal cell-derived extracellular vesicles contribute to peripheral de novo induction of Foxp3+ regulatory T cells

Pasztoi, Maria, Joern Pezoldt, Michael Beckstette, Christoph Lipps, Dagmar Wirth, Manfred Rohde, Krisztina Paloczi, Edit Iren Buzas, and Jochen Huehn.
European Journal of Immunology.

Extracellular vesicles from adipose-derived mesenchymal stem cells down-regulate senescence features in osteoarthritic osteoblasts

Tofiño-Vian, Miguel, Maria Isabel Guillén, María Dolores Pérez del Caz, and Miguel Angel.

Izon Resources

qEVoriginal Brochure

Izon Science qEVoriginal Size Exclusion Columns for EV separation and purification

Isolation of Extracellular Vesicles from Plasma

Van Deun, J., et. al., “The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling,” Journal of Extracellular Vesicles, 2014;3:10.3402/jev.v3.24858. doi:10.3402/jev.v3.24858

Lobb, RJ, et al., “Optimized exosome isolation protocol for cell culture supernatant and human plasma”, Journal of Extracellular Vesicles, 2015;4:10.3402/jev.v4.27031. doi:10.3402/jev.v4.27031.

qEVsingle Brochure

Single-use size-exclusion chromatography columns for analytical scale Extracellular Vesicle isolation.

Tunable Resistive Pulse Sensing: Essential information about nanoparticles is revealed quickly and accurately

This white paper explores key aspects for nanoparticle characterisation and compares a number of available techniques.

Izon qEV: a new tool for rapid EV isolation

This white paper introduces the qEV, a Size Exclusion Chromatography (SEC) separation technology specifically developed to address the existing obstacles in routine EV extraction. qEV is rapid, gentle, non-aggregating, highly purifying, cost effective and easily
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New qNano Gold for 2015, now very fast as well as being the most accurate

Tunable Resistive Pulse Sensing (TRPS) Brochure

TRPS is the most powerful nanoparticle characterisation system available. Recent developments mean that TRPS is now rapid and convenient, with a suite of additional tools available to make life easier for the TRPS user.

Analysing Extracellular Vesicles using TRPS

A white paper focused on EV analysis by tunable resistive pulse sensing (TRPS) complemented by size exclusion chromotography (SEC) isolation.

Integrated Platform for EV Analysis: SEC (qEV) + TRPS (qNano)

An Application Note for the combined use of standardised, quality assured SEC columns (qEV) with TRPS. The combined method is simple and practical and for the first time offers an accurate and standard solution to the separation and measurement of extracellular vesicles. The adoption of a standard technique is essential if EVs are to be used as reliable biomarkers for health analysis.