Tunable nanopore research published highlighting accuracy of single particle detection
Two journal articles have recently been published which validate the size resolution capability of Izon’s tunable nanopore technology. Both papers highlight the ability of the technology to count and characterize particles on an individual basis and therefore to differentiate between particle populations.
Dr. Seth Roberts and his colleagues at the Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, have recently had a paper published in Small entitled ‘Tunable Nano/Micropores for Particle Detection and Discrimination: Scanning Ion Occlusion Spectroscopy ‘ - Early View (article on-line in advance of print) available.
The paper outlines research carried out by the team into the dynamics of the tunable nanopore and the SIOS technology developed by Izon. The authors conclude that the tunable nanopore provides the ability to distinguish between nanoparticle populations of similar size and to detect DNA modification of nanoparticles. They also conclude that the results illustrate the potential of the novel tunable pore technique as a tool for nanoparticle characterization, as well as for nano-biotechnology applications.
‘In contrast to static or dynamic light scattering techniques, which average the properties of colloids over the entire population and cannot resolve multimodal, polydisperse particle populations, SIOS provides information on individual particles as they sequentially traverse the pore, building a distribution from the ground up and allowing the discrimination of particle populations in a mixed sample. ‘
Dr. Geoff Willmot and his colleagues have also been researching the capabilities of the tunable nanopore, and have recently had a paper published in the Journal of Physics: Condensed Matter entitled ‘Use of tunable nanopore blockade rates to investigate colloidal dispersions’ J. Phys.: Condens. Matter 22 (2010) 454116 (11pp).
The paper outlines two experiments demonstrating the potential of tunable nanopores for characterizing colloidal dispersions – one that looks at the concentration of unknown samples, and the other studying the electophoretic mobility at the level of individual particles.
‘The paper highlights the timeliness and efficiency of the tunable nanopores compared to other existing techniques available to characterize colloidal charge, concentration and other interesting parameters’