We would like to thank members of the international TRPS research community who contributed to the annual research symposium this year, held at St. Hugh's College, Oxford University, for making it a successful event.
AMC Researchers demonstrate basis of new product for EV community. Isolation of extracellular vesicles from plasma is a challenge due to the presence of proteins and lipoproteins. Isolation of vesicles using differential centrifugation or density-gradient ultracentrifugation results in co-isolation of contaminants such as protein aggregates and incomplete separation of vesicles from lipoproteins, respectively.
The properties and methods of production of micron sized, lipid stabilized bubbles of gas, known as 'microbubbles' (MBs) are being studied in detail using microfluidics by Sally Peyman and colleagues at the University of Leeds. The work was presented at the annual Izon Science research symposium held at Oxford University earlier last month.
This 3 year post-doctoral position is fully funded by the British Heart Foundation to study adipocyte-derived extracellular vesicles and their influence on vascular function.
The work forms part of a vascular biology research group at the Wales Heart Research Institute, Cardiff University School of Medicine, led by Dr Philip James focussing on the isolation, detection and characterisation of extracellular vesicles to study fundamental aspects of cardiovascular disease. Previous experience in these areas would be a significant advantage.
We are pleased to release a final programme for the Izon Science Research Symposium, which will be held in Oxford, UK next week, from 11-12 September 2014. We have an outstanding line up of speakers confirmed for the event, and this year looks to be our best symposium so far.
Prof. Dhimiter Bello's group at UMass Lowell explored for the first time the utility of nanopore based Tunable Resistive Pulse Sensing (TRPS) technology and optimized its use for characterization of engineered nanomaterial dispersions in cell culture medium containing serum, conditions applicable to in vitro nanotoxicology studies.
Researchers at the National Center for Biodefense and Infectious Diseases, George Mason University recently received the qNano which they used in a new paper, Chung et al. 2014 "Chitinases Are Negative Regulators of Francisella novicida Biofilms" (Open Access).
Prof. Rinti Banerjee and members of her group in the Nanomedicine laboratory at the Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, are developing smart, trigger responsive biodegradable nanoparticles and nanomaterials for drug delivery and tissue engineering.
Protein aggregation has become a focus for Belgium-based contract laboratory Anabiotec, as it is a key concern in biopharmaceutical production. This is due not only to the risk associated with changes to a products quality or pharmacokinetics, but most importantly because of the hazard of inducing an unwanted immune response, which is more likely to occur with particles in the subvisible and submicron range.
The 3rd International Izon Science Research Symposium will be held in Oxford, UK from 11-12 September 2014. Izon instrument users are invited to submit talks featuring new research using the Tunable Resistive Pulse Sensing (TRPS) platform. We will be organizing the presentations into the following categories: Particle-based Nanomedicine Extracellular Vesicle Analysis Virology, vaccines and gene therapy Colloids, bubbles and other nano- and micro- particle analysis; and TRPS Research and Diagnostic Applications.