Accurate characterization of the physical properties of drug delivery particles is important as developing effective drugs requires the creation of homogenous particle samples, of known concentration, that are stable and retain their drug payload.
Tunable Resistive Pulse Sensing (TRPS) is a powerful non-optical technique being used by researchers to quantify important physical properties (size, surface charge and concentration) of drug delivery particles with unsurpassed accuracy. TRPS enables:
- Measurement of Polydispersity & Aggregation of Drug Delivery Particles
- Concentraiton Determination of Drug Delivery Particle Samples
- Measurement of Drug Delivery Particle Surface Modification
Liposome Measurement on the qNano
Tunable resistive pulse sensing (TRPS) represents a new and more comprehensive technology for measuring the properties (size, charge, and concentration) of liposomal dispersions where highly sensitive and accurate analysis is required. Based on particle-by-particle analysis TRPS enables the accurate measurement of all these properties to be made from a single analysis run. TRPS provides information on both the particle concentration and the volume fraction of delivered liposome to administered solution volume that is unbiased by the size or polydispersity of the sample. In addition to measuring concentration, TRPS is a highly sensitive technique for analyzing liposome size distribution, which is critical for liposome manufacture, formulation and delivery applications.