Biosensing nanoparticles are a particularly promising area for the development of new diagnostic tools; their small size and easily-modified surfaces allow for high specificity and sensitivity.
When formulated as part of a biosensing system, nanoparticle probes act as an identifying receptor; when the target molecule binds to the nanoparticle receptor, it modifies the properties of the nanoparticle in a way that is detectable and measureable by a transducer. It is critical that the transducer can sufficiently and precisely characterize the biologic reaction.
Tunable Resistive Pulse Sensing (TRPS) offers a rapid, reliable means of measuring the size, concentration, and charge of nanoparticles. qNano is useful for multiple stages of the biosensing process development; the instrument can rapidly confirm the characteristics of a) unfunctionalised nanoparticles, b) the surface functionalisation of the nanoparticle probe, and c) the resulting target-receptor conjugation.
Femtomolar-level detection of Biological Analytes
Recent work on Izon Science’s qNano has demonstrated the detection and measurement of biological analytes down to femtomolar concentration levels. The method uses magnetic particle systems and can be applied to any biological particle or protein for which specific antibodies exist.
Platform for Diagnostics Research
Izon’s instruments have successfully characterized several particle types at each stage of the biosensing process. Some examples include:
- Dye-doped nanoparticles
- Gold nanoparticles
- Magnetic beads